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Arimidex and weight gain:
(sometimes called an AI). It is usually provided in 1MG tabs or in liquid form. The drug works in a non-steroid form by inhibiting the aromatase enzyme which convertstestosterone and other androgens into estrogen. This means that there is less estrogen tocause female pattern fat deposits, gyno, and water retention. In medicine, Arimidex isutilized to treat prostate cancer. In sports chemistry, the drug has been employed as ameans of preventing excessive estrogenic side effects during AAS use and to aid increating a harder appearing musculature for competitive bodybuilders. Unlike Nolvadex,which simply block estrogen receptor-sites, this drug prevents or reduces estrogenproduction. Though some estrogen presence is noted as necessary for AAS to reach fulleffectiveness, too much can cause a layer of fat, water retention, and breast tissue growthpotentially with tumors called gynecomastia or bitch tits. Arimidex has a 75-85%aromatization inhibition rate. Males who experienced excessive aromatization of AAS or who were extremelyestrogen sensitive usually utilized a dosage of 0.5-3.0 mg daily. In fact, most realizedexcellent estrogen control with only 0.5mg/d (mg daily). Women usually showedexcellent lean appearances (even in their legs) with 0.5-1.0 mg daily. Arimidex has a veryshort active-life so 0.5 mg dosages were often taken 2-6 times daily at equal intervals.Stacking 10-30 mg of Nolvadex with 1.0 mg of Arimidex has resulted in a near "0"estrogen activity situation regardless of the AAS protocol utilized. Directly following anAAS cycle, estrogen control has also become a problem (during periods intended for reestablishingHPTA function). In this case, the dosage was reduced from a higher startingdosage to a low dosage that was continued for 7-14 days after AAS discontinuance. Thisprotocol was considered necessary to assure clearing of AAS induced estrogen build-up.
Reported Characteristics
Active-Life: 4-6 hours Drug Class: Aromatase inhibitor (Oral) Average Reported Dosage: 0.5-3.0 mg daily Acne: No Water Retention: None Liver Toxic: Yes dosage dependent Decreases HPTA function: Increases it.
TRADE NAMES:
ARIMIDEX .25 MG TABS (International Pharmaceuticals) ARIMIDEX 1mg TABS (British Dragon)
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Lipid Peroxidation and Antioxidant System in Rats Acutely Treated with AcetoneThe objective of the present study was to determine the effects of acute treatment (AT) with acetone on the oxidative and metabolic status of rats. The AT group (n=16) was treated by gavage with a single administration of 7.0 g acetone/kg body weight at a concentration of 25% (m/v). Eight rats were euthanized 6 h later (AT6) and eight 24 h later (AT24). Acetone levels were determined in blood and urine and oxidative parameters were analyzed by determining thiobarbituric acid reactive species (TBARS, indicators of lipid peroxidation) and reduced glutathione (GSH) and vitamin E as antioxidant parameters. Serum glucose, blood cholesterol and triglycerieds and hepatic fat were also determined. The results indicated a significant difference in the hepatic oxidative parameters,...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Free radical scavenging activity ofRathod N R, Raghuveer I, Chitme H R, Chandra RIndian Journal of Pharmaceutical Sciences 2009 71(6):615-621Swarnabhasma , an Ayurvedic preparation containing Calotropis gigantea R. Br. (Asclepiadaceae) is extensively used by Ayurvedic physicians for treatment of diabetes mellitus, bronchial asthma, rheumatoid arthritis and nervous disorders. In the present study, we report the effect of chloroform extracts of Calotropis gigantea leaf and flower on free radical scavenging activity, and lipid profile in streptozotozin-induced diabetic rats. The lipid peroxidation, superoxide dismutase, and catalase were measured in liver homogenate and serum glutamic pyruvic transaminase, serum glutamic oxaloacetic transaminase, alkaline phosphatase, lipid profile were measured in blood serum. Administration ...
Does Getting Fat Protect against Fat?Everyone knows that obesity is bad for your health. Packing on the pounds, we’re told, leads to all sorts of medical problems: high cholesterol, insulin resistance, greater risk of diabetes and heart disease. But researchers at the University of Texas Southwestern Medical Center see things a little differently. In a paper in the journal Trends in Endocrinology and Metabolism [see http://bit.ly/bKaP33 ], they argue that being fat can actually protect us from these disorders. [More] (Source: Scientific American - Official RSS Feed)
Health Care Partnership Examined In Canadian Medical Association JournalA research team from the Laval Centre de sante et de services sociaux, Universite de Montreal and McGill University Health Centre has examined the benefits of greater collaboration between family physicians and community pharmacists for select patients. Published in the March 8 edition of the Canadian Medical Association Journal, the research project focused on patients with high levels of cholesterol who are at risk of cardiovascular disease. In all, 77 family physicians, 108 community pharmacists and 225 patients were recruited for the study... (Source: Health News from Medical News Today)
D-4F, an Apolipoprotein A-I Mimetic Peptide, Promotes Cholesterol Efflux from Macrophages via ATP-Binding Cassette Transporter A1.In conclusion, these results suggest that the synthetic peptide D-4F promotes cholesterol efflux in macrophages through the cAMP-PKA-ABCA1 pathway, which may open new avenues for the treatment of atherosclerosis.
PMID: 20208418 [PubMed - as supplied by publisher] (Source: The Tohoku Journal of Experimental Medicine)
Collaborative Care Plans Between Physicians And Pharmacists Have Little Impact On Clinical OutcomesThe use of a physician-pharmacist collaborative care plan to manage lipid control in patients with high cholesterol does not have significant clinical impact, found an article in CMAJ (Canadian Medical Association Journal). The role of community pharmacists is expanding worldwide. More than 40 states in the US have collaborative practice laws and in Quebec, pharmacists can start and adjust drug therapy in accordance with a physician's prescription... (Source: Health News from Medical News Today)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Obesity As Protection Against Metabolic Syndrome, Not Its CauseThe collection of symptoms that is the metabolic syndrome - insulin resistance, high cholesterol, fatty liver, and a greater risk for diabetes, heart disease, and stroke - are all related to obesity, but, according to a review in the March 9th issue of the Cell Press publication Trends in Endocrinology and Metabolism, not in the way you probably think they are... (Source: Cholesterol News From Medical News Today)
Obesity As Protection Against Metabolic Syndrome, Not Its CauseThe collection of symptoms that is the metabolic syndrome - insulin resistance, high cholesterol, fatty liver, and a greater risk for diabetes, heart disease, and stroke - are all related to obesity, but, according to a review in the March 9th issue of the Cell Press publication Trends in Endocrinology and Metabolism, not in the way you probably think they are. In fact, says Roger Unger of the University of Texas Southwestern at Dallas, obesity is the body's way of storing lipids where they belong, in fat tissue, in an effort to protect our other organs from lipids' toxic effects... (Source: Health News from Medical News Today)
Obesity as protection against metabolic syndrome, not its causeThe collection of symptoms that is the metabolic syndrome -- insulin resistance, high cholesterol, fatty liver, and a greater risk for diabetes, heart disease, and stroke -- are all related to obesity, but, according to a new review not in the way you probably think they are. (Source: ScienceDaily Headlines)
Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammationConclusion and implications: Chronic pioglitazone administration reduced hepatic inflammatory responses in rats fed a HCF diet. These effects were associated with changes in hepatic expression of SOCS-3, which may be a crucial link between the reduced local inflammation and the improved insulin signalling. (Source: British Journal of Pharmacology)
Preadmission statin use and one-year mortality among patients in intensive care - A cohort studyConclusions:
Preadmission statin use was associated with reduced risk of death following intensive care. The associations seen could be a pharmacological effect of statins, but unmeasured differences in characteristics of statin users and non-users cannot be entirely ruled out. (Source: BioMed Central)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPAR alpha and SREBP-1c signalingConclusions:
According to our study, the lipids-lowering effect of dietary SSC may be partly associated with the enhancement of beta-oxidation via PPAR alpha activation. In addition, the inhibited SREBP-1c- mediated lipogenesis caused by SSC may also contribute to alleviating fatty liver. (Source: Lipids in Health and Disease)
Inhibitory Effect of Seabuckthorn (Hippophea rhamnoides) on Platelet Aggregation and Oxidative StressExtracts from seabuckthorn (Hippophea rhamnoides) leaves, fruit and seed oil were screened for anti-platelet properties in-vitro using human platelets stimulated with 0.2 mM ADP. Half maximal inhibitory concentration was found to be 55 microg/ml platelet rich plasma(PRP) for leaf extract, 47.7 microg/ml PRP for fruit extract and 0.62 microl/ml PRP for seed oil. In-vitro incubation of platelets with increasing concentrations of seed oil was found to inhibit oxidative stress in resting as well as agonist stimulated platelets as evident by decreased formation of peroxide and superoxide radicals. Leaf extract and seed oil were further evaluated for antiplatelet and antioxidant action in-vivo in cholesterol-induced experimental atherosclerosis in rabbits. Rabbits fed on diet supplemented with c...
Potential Use of 10-Year and Lifetime Coronary Risk Information for Preventive Cardiology Prescribing Decisions: A Primary Care Physician Survey [Original Investigation]Conclusions Providing 10-year coronary risk information improved some hypothetical aspirin-prescribing decisions and improved lipid management when the short-term risk was moderately high. High lifetime risk sometimes led to more intensive prescription of aspirin or lipid-lowering medication. This outcome suggests that, to maximize the benefits of risk-calculating tools, specific guideline recommendations should be provided along with risk estimates. (Source: Archives of Internal Medicine)
Spirulina Improves Antioxidant Status by Reducing Oxidative Stress in Rabbits Fed a High-Cholesterol DietJournal of Medicinal Food , Vol. 0, No. 0. (Source: Journal of Medicinal Food)
Women Benefit as Much as Men From Statins for Primary Prevention of CVDStatin use by women cuts their risk of primary cardiovascular disease (CVD) events by roughly a third, which is similar to the risk reduction seen in men, research shows. Reuters Health Information (Source: Medscape Cardiology Headlines)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Cutting Feedback in Bayesian Regression Adjustment for the Propensity ScoreMcCandless, Gustafson and Austin (2009) describe a Bayesian approach to regression adjustment for the propensity score to reduce confounding. A unique property of the method is that the treatment and outcome models are combined via Bayes theorem. However, this estimation procedure can be problematic if the outcome model is misspecified. We observe feedback that can bias propensity score estimates. Building on new innovation in Bayesian computation, we propose a technique for cutting feedback in a Bayesian propensity analysis. We use the posterior distribution of the propensity scores as an input in the regression model for the outcome. The method is approximately Bayesian in the sense that it does not use the full likelihood for estimation. Nonetheless, it severs feedback between the treat...
Wine and women's weightConclusion
This large cohort study that followed middle-aged women for almost 13 years found that there was an association between greater alcohol consumption and slightly slower weight gain over this period.
Despite the tone of press coverage, it should be remembered that this type of study can only show associations between factors, and cannot say how or whether alcohol directly causes the slower weight gain. There are also a number of limitations to this research, some of which the researchers have highlighted:
The participants self-reported their weights and alcohol consumption, which may have resulted in a misclassification or underestimation of these values.
The study used a single measurement of alcohol consumption taken at the start of the study. It is likely that the partici...
NSAID, Statin Use May Cut Cancer Risk With PPI-Treated Barrett's EsophagusA study shows that nonsteroidal anti-inflammatory drugs and statins can nearly halve the risk for esophageal adenocarcinoma in patients taking proton-pump inhibitors for Barrett's esophagus. Reuters Health Information (Source: Medscape Hematology-Oncology Headlines)
Processed Meat May Harm the HeartTitle: Processed Meat May Harm the HeartCategory: Health NewsCreated: 3/5/2010 8:10:00 PMLast Editorial Review: 3/8/2010 (Source: MedicineNet Cholesterol General)
Teamwork Unlikely to Improve Cholesterol LevelsTitle: Teamwork Unlikely to Improve Cholesterol LevelsCategory: Health NewsCreated: 3/8/2010 10:10:00 AMLast Editorial Review: 3/8/2010 (Source: MedicineNet Cholesterol General)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Obesity as protection against metabolic syndrome, not its cause(Cell Press) The collection of symptoms that is the metabolic syndrome -- insulin resistance, high cholesterol, fatty liver, and a greater risk for diabetes, heart disease, and stroke -- are all related to obesity, but, according to a review in the March 9 issue of the Cell Press publication Trends in Endocrinology and Metabolism, not in the way you probably think they are. (Source: EurekAlert! - Biology)
Physician-pharmacist collaborative care plans have little impact on clinical outcomes(Canadian Medical Association Journal) The use of a physician-pharmacist collaborative care plan to manage lipid control in patients with high cholesterol does not have significant clinical impact, found an article in CMAJ. (Source: EurekAlert! - Social and Behavioral Science)
'Improved doctor-pharmacist collaboration needed': study(University of Montreal) A research team from the Laval Centre de sante et de services sociaux, Universite de Montreal and McGill University Health Centre has examined the benefits of greater collaboration between family physicians and community pharmacists for select patients. Published in the March 8 edition of the Canadian Medical Association Journal, the research project focused on patients with high levels of cholesterol who are at risk of cardiovascular disease. (Source: EurekAlert! - Medicine and Health)
Cholesterol Drugs May Treat PsoriasisA study shows cholesterol-lowering statins may help treat psoriasis. (Source: WebMD Health)
Corporate executives’ adherence to statins poorResults from a study of corporate executives show that only 68% took statins as prescribed by their doctor. (Source: MedWire News - Lipidology)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Lipid levels in sickle-cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertensionPulmonary hypertension (PH) in sickle cell disease (SCD) is an emerging and important clinical problem. In a single-institution adult cohort of 365 patients, we investigated lipid and lipoprotein levels and their relationship to markers of intravascular haemolysis, vascular dysfunction and PH. In agreement with prior studies, we confirm significantly decreased plasma levels of total cholesterol, high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) in SCD versus ethnically-matched healthy controls. Several cholesterol parameters correlated significantly with markers of anaemia, but not endothelial activation or PH. More importantly, serum triglyceride levels were significantly elevated in SCD compared to controls. Elevated triglyceride levels correlat...
How meditation can improve leaders' performanceThe role of a leader in organizations is one of constant pressure to perform and stress to solve problems. Leaders need to be at the top of their game to be alert and productive at all times. Unfortunately, far too many leaders use adrenalin-type of strategies to do so, such as caffeine, long working hours and poor nutrition. Certainly the notion of slowing down and being in a peaceful state isn't commonly seen as an effective leadership strategy. Yet recent brain research shows that meditation can actually improve performance.A study at American University and published in a special issue of Cognitve Processing, dedicated to meditation and consciousness in February, 2010, concluded that meditation, carried out effectively, produced a unique state of "restful alertness," as seen in the mar...
Comparative antilipidemic effect of N-acetylcysteine and sesame oil administration in diet-induced hypercholesterolemic miceConclusion:
Co-administration of NAC, but not sesame oil, restored the disturbed lipid profile and improved hepatic steatosis in the studied diet-induced hypercholesterolemic mice. Both agents appear to ameliorate serum antioxidant defense. (Source: BioMed Central)
Winning from Boosting Good Cholesterol (RVXCF, RVX, PFE, AZN, MRK)BioHealthInvestor usually sticks to US companies or at least sticks to ADRs for investors. But sometimes there is a much larger bit of data either north of the border or in Europe. There is a company called Resverlogix Corp. which trades in Canada under the ticker ‘RVX’ and the stock also trades in the US on the Pink Sheets under the ticker ‘RVXCF.’ The stock is soaring today after Bloomberg gave a very positive article highlighting the merits of the company’s RVX-208. This potential drug candidate is targeting atherosclerosis in acute coronary syndrome patients. The target is to raise HDL levels to effectively reverse arterial plaque buildup. The company noted that there are approximately 350 million patients that require treatment for atheroscl...
CD10 enhances metastasis of colorectal cancer by abrogating the anti-tumoural effect of methionine-enkephalin in the liverConclusion
CD10 expression in CRC cells abrogates the anti-tumour effect of hepatic MENK by degrading it, which enhances liver metastasis of CD10-positive CRC cells. (Source: Gut)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Nuts, blood lipids and cardiovascular disease.Authors: Sabate J, Wien M
The aim of this paper is to evaluate nut-related epidemiological and human feeding study findings and to discuss the important nutritional attributes of nuts and their link to cardiovascular health. Frequent nut consumption has been found to be protective against coronary heart disease in five large epidemiological studies across two continents. A qualitative summary of the data from four of these studies found an 8.3% reduction in risk of death from coronary heart disease for each weekly serving of nuts. Over 40 dietary intervention studies have been conducted evaluating the effect of nut containing diets on blood lipids. These studies have demonstrated that intake of different kinds of nuts lower total and LDL cholesterol and the LDL: HDL ratio in healthy su...
Prevalence and characteristics of the metabolic syndrome among adults in Beijing, China.This study was performed to investigate the prevalence of the metabolic syndrome using a large representative sample in Beijing. Data from a total of 16442 adults (6489 men and 9953 women) aged ?18 years from a survey of behavioral risk factors for chronic diseases in Beijing, in 2005, was analyzed. The prevalence of the metabolic syndrome increased with age and the age-standardized prevalence of the metabolic syndrome defined by International Diabetes Federation IDF and National Cholesterol Education Program Adult Treatment Panel III ATPIII criteria were 23.2% (24.5% in men and 22.7% in women) and 16.2% (16.1% in men and 16.6% in women), respectively. The metabolic syndrome was higher in semi-urban areas and associated with higher rates of hypertension, central obesity, salt intake and sm...
High prevalence of low HDL-c in the Philippines compared to the US: population differences in associations with diet and BMI.Authors: Rutherford JN, McDade TW, Feranil AB, Adair LS, Kuzawa CW
Cardiovascular disease (CVD) is a leading cause of death in the Philippines, although few studies here have examined the lipid profiles underlying disease risk. The isolated low high density lipoprotein cholesterol (HDL-c) phenotype has been implicated as a CVD risk factor, the prevalence of which exhibits significant variation across populations. To assess population variation in individual lipid components and their associations with diet and anthropometric characteristics, we compare lipid profiles in a population of adult Filipino women (n=1877) to US women participating in the National Health and Nutrition Examination Survey (NHANES, n=477). We conducted multiple regression models to assess the relationship between...
Dietary patterns by reduced rank regression predicting changes in obesity indices in a cohort study: Tehran Lipid and Glucose Study.Conclusions: The results were indicative of a traditional pattern which is dominated in the Tehran region and associated with increase in obesity indices.
PMID: 20199984 [PubMed - in process] (Source: Asia Pacific Journal of Clinical Nutrition)
Regular painkillers and hearing lossConclusion
This study found an association between regular use of three types of painkiller and a small increased risk in hearing loss. This type of study can only find associations, it cannot demonstrate that these painkillers caused the hearing loss. The researchers highlight some limitations of their study:
Men were categorised as having hearing loss based on their own admission in the questionnaire on whether it had been diagnosed by a professional. Participants who did not report hearing loss were considered to not be impaired. The best way to assess hearing would have been through standard pure-tone audiometry, but this could not be performed due to cost and logistics reasons.
The researchers did not have information on the participants’ lifetime noise exposure or the reasons...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Development of a Scaleable Process for the Synthesis of a Next-Generation StatinOrganic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Effects of lovastatin on breast cancer cells: a proteo-metabonomic studyConclusions:
The combination of proteomics and metabonomics enabled us to identify several key targets essential to the antitumor activity of lovastatin. Our results imply that lovastatin has the potential to reduce the growth of breast cancer cells. (Source: Breast Cancer Research)
Adiponectin linked to cardiometabolic factors in PCOS womenStudy results show that in women with polycystic ovary syndrome, levels of adiponectin are linked to insulin resistance, high-density lipoprotein cholesterol, and abdominal adiposity, but are unrelated to metformin treatment. (Source: MedWire News - Lipidology)
Polyphenols and cholesterol efflux: is coffee the next red wine?Authors: Burke MF, Khera AV, Rader DJ
PMID: 20203311 [PubMed - in process] (Source: Circulation Research)
Highly sensitive C-reactive protein and male gender are independently related to the severity of coronary disease in patients with metabolic syndrome and an acute coronary event.The objective of this study was to examine the major determinants of coronary disease severity, including those coronary risk factors associated with metabolic syndrome, during the early period after an acute coronary episode. We tested the hypothesis that inflammatory markers, especially highly sensitive C-reactive protein (hsCRP), are related to coronary atherosclerosis, in addition to traditional coronary risk factors. Subjects of both genders aged 30 to 75 years (N = 116) were prospectively included if they had suffered a recent acute coronary syndrome (acute myocardial infarction or unstable angina pectoris requiring hospitalization) and if they had metabolic syndrome diagnosed according to the National Cholesterol Education Program/Adult Treatment Panel III. Patients were submitted t...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Cholesterol Drugs May Fight Asthma, TooA study shows a link between statins and improved lung function in asthma patients. WebMD Health News (Source: Medscape Today Headlines)
Insulin resistance may enhance statin responseInsulin resistance is associated with an enhanced response to statin therapy, research suggests. (Source: MedWire News - Lipidology)
Ten-year increase in the prevalence of obesity and reduction in fat intake in Brazilian women aged 35 years and olderConclusion
In line with an advertised reduction in fat intake, Brazilian women at greatest risk of obesity had a reduction in fat intake and cholesterol, and increased intake of carbohydrate. This group needs to be given a clear message regarding energy reduction in order to curb the obesity epidemic. (Source: Journal of Epidemiology and Community Health)
Rosuvastatin Prevents Conduit Artery Endothelial Dysfunction Induced by Ischemia and Reperfusion by a Cyclooxygenase-2–Dependent MechanismConclusions: Rosuvastatin pharmacologically prevents the development of IR-induced conduit artery endothelial dysfunction. This beneficial effect of rosuvastatin is mediated by a COX-2–dependent mechanism, evidence that may also provide potential mechanistic insight into the reported cardiotoxic effects of COX-2 inhibitors. (Source: Journal of the American College of Cardiology)
Classification of hypocholesterolemia lipid patterns using Chol/Trig Combination System.Authors: Ooi K, Sugimoto K, Shiraki K, Yamamoto N, Tameda M, Beppu T, Tanaka J, Nojiri K, Kusagawa S, Takei Y, Masuda C, Nobori T
Patterns of hypocholesterolemic lipid fractions in 295 patients with liver diseases, malignant tumors, arteriosclerotic and renal diseases with cholesterol (Chol) levels of <30 mg/dl were classified using a simultaneous analytical method for the Chol and triglyceride (TG) fractions (Chol/Trig Combo System). Hypocholesterolemia was classified as follows: IV, Type IV on WHO hyperlipidemia phenotype classification; intermediate density lipoprotein (IDL), cases with appearance of IDL, including appearance of Lp(a); high + low density lipoproteins (HDL+LDL), lipids mostly consisting of HDL and LDL fractions; HDL abnormality, cases with slow alphaHDL or fast HD...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Association of genetic variants with myocardial infarction in Japanese individuals with different lipid profiles.Authors: Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y
Dyslipidemia is an important risk factor for myocardial infarction (MI). We previously showed that gene polymorphisms associated with MI differed among individuals with different lipid profiles. We further examined whether genetic variants that confer susceptibility to MI might differ among individuals with low or high serum concentrations of triglycerides, high density lipoprotein (HDL)-cholesterol, or low density lipoprotein (LDL)-cholesterol. The study population comprised 5270 Japanese individuals, including 1188 subjects with MI and 4082 controls. The 150 polymorphisms examined in the present study were selected by genome-wide association studies of MI and ischemic ...
Even The Boss Doesn't Follow The Doctor's OrdersOnly 68 percent of corporate executives took their cholesterol lowering medication as prescribed by a doctor, a new study shows. Overall, the executives who took their medication even sporadically were twice as likely to meet their cholesterol goals. The study finding also questions the prevailing wisdom that income is a primary factor in medication adherence... (Source: Health News from Medical News Today)
Even The Boss Doesn't Follow The Doctor's OrdersOnly 68 percent of corporate executives took their cholesterol lowering medication as prescribed by a doctor, a new study shows. Overall, the executives who took their medication even sporadically were twice as likely to meet their cholesterol goals. The study finding also questions the prevailing wisdom that income is a primary factor in medication adherence... (Source: Statins News From Medical News Today)
Prostate cancer therapy can increase risk of heart disease and death(NaturalNews) A new report published in the American Cancer Society journal, CA: A Cancer Journal for Clinicians, and in the American Heart Association journal, Circulation, reveals that androgen-deprivation therapy (ADT), a type of prostate cancer treatment, can increase heart risk factors and possibly lead to heart attack or cardiac death.A writing group of experts from the American Heart Association, the American Cancer Society, the American Urological Association, and the American Society for Therapeutic Radiology and Oncology published their findings that indicate that ADT leads to increased fat mass, increased low-density lipoprotein (LDL) cholesterol, the "bad" form of cholesterol, and blood sugar abnormalities.The goal of ADT is to reduce male hormonal levels in order to decrease t...
You Can't Exercise Away TV's Toll on the HeartTitle: You Can't Exercise Away TV's Toll on the HeartCategory: Health NewsCreated: 3/3/2010 2:10:00 PMLast Editorial Review: 3/4/2010 (Source: MedicineNet Cholesterol General)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
A Cheek Swab to Choose Your Diet Plan?Title: A Cheek Swab to Choose Your Diet Plan?Category: Health NewsCreated: 3/3/2010 4:10:00 PMLast Editorial Review: 3/4/2010 (Source: MedicineNet Cholesterol General)
Potassium-Rich Foods Do a Heart GoodTitle: Potassium-Rich Foods Do a Heart GoodCategory: Health NewsCreated: 3/3/2010 8:10:00 PMLast Editorial Review: 3/4/2010 (Source: MedicineNet Cholesterol General)
Chocolate May Make Some Strokes Less LikelyTitle: Chocolate May Make Some Strokes Less LikelyCategory: Health NewsCreated: 3/3/2010 8:10:00 PMLast Editorial Review: 3/4/2010 (Source: MedicineNet Cholesterol General)
Why mobility scooters can increase your risk of diabetes and heart diseaseA study of scooter users in the U.S. found nearly one in five developed diabetes after buying one to get around. Many also needed to be prescribed higher doses of blood pressure pills and statins. (Source: the Mail online | Health)
Diet quality and anthropometry between different sailboarding stylesConclusion: Overall findings suggest the need for dietary counselling in windsurfers, as glycogen depletion is crucial in sailboarding, where one athlete consists of the total boat crew thus, glycogen depletion leading to insufficient energy for technical movements while sailing, has direct effect on the result of the race. (Source: Nutrition and Dietetics)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Soy Goes to School: Acceptance of Healthful, Vegetarian Options in Maryland Middle School LunchesCONCLUSIONS: This study indicates that middle school students readily consume almost equal numbers of soy-based products compared to popular school lunch items. Soyfoods provide nutritional advantages. (Source: Journal of School Health)
A Pharmacogenetics-based Approach to Reduce Cardiovascular Mortality with the Prophylactic Use of StatinsAbstract: Nitric oxide (NO) is the main endothelial-derived relaxation factor and plays a major role in cardiovascular homeostasis. This key signalling molecule is synthesised by a family of nitric oxide synthases (NOS), and the endothelial isoform (eNOS) is the most important for nitric oxide formation in the cardiovascular system. Cardiovascular drugs including statins increase eNOS expression and up-regulate NO formation, and this effect may be responsible for protective, pleiotropic effects produced by statins. However, the genetic background may also affect NO formation in the cardiovascular system, and recent studies have shown that genetic polymorphisms in the eNOS gene modify endogenous NO formation and the risk of developing cardiovascular diseases. For example, cases with the CC ...
Virus Removal and Eradication by Modified Double Filtration Plasmapheresis Decreases Factor XIII LevelsFactor XIII (FXIII) deficiency increases the chance for pathological bleeding, but this disorder cannot be detected by routine laboratory tests. Virus removal and eradication (VRAD, the trademark of Asahikasei Kuraray Medical) by double filtration plasmapheresis (DFPP) is an effective technique used to eradicate the hepatitis C virus in people afflicted with the disease. We have previously reported that DFPP significantly reduced FXIII in those undergoing this treatment. VRAD is a modified type of DFPP with a larger pore size of the second filter compared to conventional DFPP. Because VRAD may have similar effects on FXIII levels, we investigated the kinetics of FXIII during the course of VRAD therapy. A retrospective, observational study of the patients who underwent VRAD between July 200...
Statin Reduces Cardiovascular Events, Mortality in CKDRosuvastatin (Crestor) reduces all-cause mortality and the incidence of first cardiovascular events
among subjects with moderate chronic kidney disease, low-density lipoprotein cholesterol of less than 130 mg/dL,
and elevated high-sensitivity C-reactive protein, according to research published online March 3 in the Journal of
the American College of Cardiology. (Source: Modern Medicine)
Improved Lipid and Glucose Metabolism in Transgenic Rats With Increased Circulating Angiotensin-(1-7).CONCLUSIONS: These results show that increased circulating angiotensin-(1-7) levels lead to prominent changes in glucose and lipid metabolism.
PMID: 20203301 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Simvastatin Decreases Endothelial Progenitor Cell Apoptosis in the Kidney of Hypertensive Hypercholesterolemic Pigs.CONCLUSIONS: EPC are recruited but undergo apoptosis in the HTC kidney, likely because of a hostile microenvironment. Simvastatin rescues renal repair mechanisms in HTC and counteracts renal damage, which may account for its protective effects on the kidney during exposure to cardiovascular risk factors.
PMID: 20203299 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Reduced Activity and Expression of Mitochondrial Citrate Carrier in Streptozotocin-Induced Diabetic Rats.Authors: Gnoni GV, Giudetti AM, Mercuri E, Damiano F, Stanca E, Priore P, Siculella L
Citrate carrier (CiC), an integral protein of the mitochondrial inner membrane, plays an important role in hepatic intermediary metabolism, supplying the cytosol with acetyl-coenzyme A for fatty acid and cholesterol synthesis. Here, the effect of streptozotocin-induced diabetes on CiC activity and expression in rat liver was investigated. The rate of citrate transport was reduced by about 35% in mitochondria from diabetic vs. control rats. Kinetic studies in mitochondria from diabetic rats showed a reduction in maximum velocity and almost unchanged Michaelis-Menten constant of the CiC protein. Mitochondrial phospholipid amount was not significantly affected, whereas an increase in the cholesterol cont...
Hepatocyte Growth Factor and the Risk of Ischemic Stroke Developing Among Postmenopausal Women. Results From the Women's Health Initiative.CONCLUSIONS: Circulating levels of HGF are associated with an increased risk of incident ischemic stroke, independent of obesity and other risk factors for cardiovascular disease, among postmenopausal women aged 50 to 79 years.
PMID: 20203323 [PubMed - as supplied by publisher] (Source: Stroke)
Serum Potassium and Outcomes in CKD: Insights from the RRI-CKD Cohort Study.CONCLUSIONS: Although clinical practice usually emphasizes greater attention to elevated S(K) in the setting of CKD, our results suggest that patients who have CKD and low or even low-normal S(K) are at higher risk for dying than those with mild to moderate hyperkalemia.
PMID: 20203167 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Effect of Membrane Permeability on Inflammation and Arterial Stiffness: A Randomized Trial.CONCLUSIONS: Our findings suggest that dialysis with polyamide membranes with different flux characteristics did not modify the inflammatory indices and lipid profile in stable HD patients; however, a seemingly beneficial effect on aortic stiffness was noted for patients who were maintained on high-flux polyamide membrane.
PMID: 20203165 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Transcriptional profiling reveals divergent roles of PPAR{alpha} and PPAR{beta}/{delta} in regulation of gene expression in mouse liverLittle is known about the role of the transcription factor peroxisome proliferator-activated receptor (PPAR) β/ in liver. Here we set out to better elucidate the function of PPARβ/ in liver by comparing the effect of PPAR and PPARβ/ deletion using whole genome transcriptional profiling and analysis of plasma and liver metabolites. In fed state, the number of genes altered by PPAR and PPARβ/ deletion was similar, whereas in fasted state the effect of PPAR deletion was much more pronounced, consistent with the pattern of gene expression of PPAR and PPARβ/. Minor overlap was found between PPAR- and PPARβ/-dependent gene regulation in liver. Pathways upregulated by PPARβ/ deletion were connected to innate immunity and inflammation. Pathways downregulated by P...
Calcium and vitamin D may not cut cholesterolNEW YORK (Reuters Health) - People looking to improve their heart health by lowering their cholesterol levels won't find help from calcium and vitamin D supplements, according to a new study. (Source: Reuters: Health)
Gardasil 95.7% effective; HIV drugs cut risk of transmission; Walnuts cut cholesterolOur update on the latest research being presented at medical conferences. (Source: Pulse)
CETP variant associated with variable cholesterol response to statin therapyVariants in the cholesteryl ester transfer protein gene and in the apolipoprotein A-I gene are associated with poor cholesterol-lowering response to statins in an elderly population, report researchers. (Source: MedWire News - Lipidology)
Interpreting The JUPITER Trial: Statins can prevent VTE, but more study is neededThe incidence of venous thromboembolism in people taking rosuvastatin (Crestor) 20 mg/day was about half that in people taking placebo. This was a relatively healthy population, and the incidence in both groups was low. (Source: Cleveland Clinic Journal of Medicine)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
If You Take Simvastatin To Control Cholesterol, Watch Out For Infection Says New ReportBETHESDA, Md., March 2, 2010-New research published in the
Journal of Leukocyte Biology suggests that simvastatin negatively
impacts the immune system's ability to clear infection and control
inflammation in the presence of bacteria.
Simvastatin... (Source: Drugs.com - Clinical Trials)
Daily aspirin 'not for the healthy'Conclusion
This trial has tried to answer an important question regarding who should be given aspirin to prevent a heart attack or stroke. It used a systematic method to screen people and followed a reasonably large group of patients for up to 10 years in some cases. The finding of “no statistical significance” can be an important result, and in this case suggests that any benefits from taking aspirin for this group of people are likely to be small. The risk of bleeding was also small and not technically of statistical significant.
There is a non-significant trend in the results towards aspirin being harmful. As there is also a suggestion that the study may have been underpowered (planned for too few people), this implies that a larger study may have detected a significant increase ...
Blood Perfluorochemical Levels Linked To Lipoprotein LevelsBOSTON - An analysis of blood serum in a sample of participants in the 2009 CDC National Health & Nutrition Examination Survey found that 98 percent had detectable levels of perfluorooctanoic acid, perfluorononanoic acid, perfluorooctane sulfonic acid and perfluorohexane sulfonic acid, and the level of compounds is correlated with cholesterol levels in the blood, according to research published online Feb. 10 in Environmental Health Perspectives (118;2:197-202).
Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News)
Naturally Occurring Glycoalkaloids in Potatoes Aggravate Intestinal Inflammation in Two Mouse Models of Inflammatory Bowel DiseaseConclusions Our results demonstrate that consumption of potato skins containing glycoalkaloids can significantly aggravate intestinal
inflammation in predisposed individuals.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1158-9Authors
Vadim Iablokov, University of Alberta Division of Gastroenterology Zeidler Ledcor Building Edmonton AB T6G 2X8 CanadaBeate C. Sydora, University of Alberta Division of Gastroenterology Zeidler Ledcor Building Edmonton AB T6G 2X8 CanadaRae Foshaug, University of Alberta Division of Gastroenterology Zeidler Ledcor Building Edmonton AB T6G 2X8 CanadaJon Meddings, University of Alberta Division of Gastroenterology Zeidler Ledcor Building Edmonton AB T6G 2X8 CanadaDarcy Driedger, Alberta Agriculture and Rural De...
Anti-hyperlipidemic Effects of Red Ginseng Acidic Polysaccharide from Korean Red Ginseng.Authors: Kwak YS, Kyung JS, Kim JS, Cho JY, Rhee MH
It has been reported that red ginseng acidic polysaccharide (RGAP), isolated from Korean red ginseng, displays immunostimulatory and anti-tumor activities. In a follow-up study, we have carried out a study on the anti-hyperlipidemic effects of RGAP using hyperlipidemic rats acutely induced by Triton WR1339 or corn oil intravenously injected. Oral administration of RGAP (100 to 1000 mg/kg) dose-dependently reduced the serum levels of triglyceride (TG) up-regulated by Triton WR1339, an inducer of endogenous model hyperlipidemia. Moreover, RGAP treatment was shown to significantly decrease the levels of non-esterified fatty acid (NEFA) concomitant with TG reduction. However, such reduction effects were not observed in cases of total chol...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Coffee May Cut Risk of Heart Rhythm ProblemsTitle: Coffee May Cut Risk of Heart Rhythm ProblemsCategory: Health NewsCreated: 3/3/2010 8:47:00 AMLast Editorial Review: 3/3/2010 8:47:47 AM (Source: MedicineNet Cholesterol General)
Study Questions Value of Test for Peripheral Artery DiseaseTitle: Study Questions Value of Test for Peripheral Artery DiseaseCategory: Health NewsCreated: 3/2/2010 4:10:00 PMLast Editorial Review: 3/3/2010 (Source: MedicineNet Cholesterol General)
Secondhand Smoke Starts Damaging Arteries in ChildhoodTitle: Secondhand Smoke Starts Damaging Arteries in ChildhoodCategory: Health NewsCreated: 3/2/2010 4:10:00 PMLast Editorial Review: 3/3/2010 (Source: MedicineNet Cholesterol General)
For Some on Dialysis, Anemia Drugs Pose RisksTitle: For Some on Dialysis, Anemia Drugs Pose RisksCategory: Health NewsCreated: 3/2/2010 4:10:00 PMLast Editorial Review: 3/3/2010 (Source: MedicineNet Cholesterol General)
Workplace Wellness Programs WorkTitle: Workplace Wellness Programs WorkCategory: Health NewsCreated: 3/2/2010 8:10:00 PMLast Editorial Review: 3/3/2010 (Source: MedicineNet Cholesterol General)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Novel preparation of intercellular lipid models of the stratum corneum containing stereoactive ceramide.In conclusion, the CER5/CHOL/PA bilayers prepared based on RSM-S and SOM were useful as models of the intercellular lipids in the stratum corneum.
PMID: 20190434 [PubMed - in process] (Source: Chemical and Pharmaceutical Bulletin)
Cholesterol Drugs May Fight Asthma, TooA study shows statin drugs -- used to lower cholesterol -- may also improve lung function in asthma patients. (Source: WebMD Health)
Clinical trials strive to find new treatments for heart alimentsDespite their best efforts, some might need a helping hand when it comes to keeping the heart healthy. Baylor College of Medicine researchers and physicians are currently working to find new treatments and prevention methods to stave off heart ailments. "Atherosclerosis, or hardening of the arteries, can sometimes have no symptoms until you have a heart attack," said Dr. Christie Ballantyne , professor and interim chief of cardiology and chief of the section of atherosclerosis and vascular medicine at BCM. "We are hoping to find ways to noninvasively assess the response to various therapies for atherosclerosis and other heart related ailments." The following studies are currently enrolling participants: AIM HIGH in cholesterol study (MRI study) Volunteers are needed for...
The glycosylphosphatidylinositol anchor is a major determinant of prion binding and replicationThe prion diseases occur following the conversion of the cellular prion protein (PrPC) into an alternatively folded, disease-related isoform (PrPSc). However, the spread of PrPSc from cell to cell is poorly understood. Here we report that soluble PrPSc bound to and replicated within both GT1 neuronal cells and primary cortical neurones. The capacity of PrPSc to bind and replicate within cells was significantly reduced by enzymatic modification of its glycosylphosphatidylinositol (GPI) anchor. Thus, PrPSc that had been digested with phosphatidylinositol-phospholipase C bound poorly to GT1 cells or cortical neurones and did not result in PrPSc formation in recipient cells. PrPSc that had been digested with phospholipase A2 (PrPSc-G-lyso-PI) bound readily to GT1 cells and cortical neurones bu...
ANTIOXIDATIVE PROPERTY AND ANTIATHEROSCLEROTIC EFFECTS OF THE POWDER PROCESSED FROM CHAENOMELES SPECIOSA IN APOE–/– MICEThis study was conducted to explore antioxidative property and antiatherosclerotic effects of the powder processed from Chaenomeles speciosa. Chaenomeles speciosa powder (CSP) was rich in vitamin C and polyphenols. The ferric reducing antioxidant power of CSP was 173 ± 7 µmol Fe2+/g and the scavenging activity on 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH[bull]) andwere 945 ± 20 µg DPPH[bull]/g and 700 ± 21 U/mL, respectively. We further tested antiatherosclerotic effects of CSP in ApoE[ndash]/[ndash] mice which was fed a high-fat diet for 16 weeks. Both 5 and 10% CSP dietary supplement significantly reduced serum low-density lipoprotein cholesterol and total cholesterol levels (P < 0.05). Comparing with normal group, there was a significant increase of glutathione peroxidase ac...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Antioxidant properties of water extracts from parching green teaCold and hot water extracts (2, 6 and 10%) were prepared from parching green tea and its antioxidant properties studied and potential antioxidant components determined. Yields of hot water extracts (17.53[ndash]28.63%) were significantly higher than those of cold water extracts (13.34[ndash]16.14%). The half maximal effective concentration (EC50) values in antioxidant activity and reducing power were 2.17[ndash]2.75 and 0.22[ndash]0.30 mg/mL, respectively. Scavenging abilities on 1,1-diphenyl-2-picrylhydrazyl radicals were comparable. EC50 values in scavenging ability on hydroxyl radicals and chelating ability on ferrous ions were 3.31[ndash]4.54 and 1.63[ndash]3.09 mg/mL, respectively. Contents of total phenols were 220.52[ndash]339.83 mg/g whereas those of total catechins in cold and hot...
Atherosclerosis induced by chronic inhibition of the synthesis of nitric oxide in moderately hypercholesterolaemic rabbits is suppressed by pitavastatinConclusion: Atherosclerosis induced by chronic inhibition of NOS in moderately hypercholesterolaemic rabbits was suppressed by pitavastatin via inhibition of macrophage accumulation and macrophage foam cell formation. (Source: British Journal of Pharmacology)
Impact of Lipid Raft Integrity on 5-HT3 Receptor Function and its Modulation by AntidepressantsAuthors: Caroline Nothdurfter, Sascha Tanasic, Barbara Di Benedetto, Gerhard Rammes, Eva-Maria Wagner, Thomas Kirmeier, Vanessa Ganal, Julia S Kessler, Theo Rein, Florian Holsboer
& Rainer Rupprecht
Keywords: 5-HT3 receptor; antidepressants; Biological Psychiatry; cholesterol; ligand-gated ion channel; lipid rafts; Psychopharmacology; Receptor Pharmacology; Serotonin (Source: Neuropsychopharmacology)
Relevance of Sphingolipids in the Pleiotropic Protective Effects of High-Density Lipoproteins.Authors: Tölle M, Schuchardt M, van der Giet M
Atherosclerosis is the major cause of cardiovascular morbidity and mortality. A multitude of pro-atherogenic mediators are known liable for the initiation and progression of atherogenic vascular lesions. Only few endogenous molecules are known so far with cardiovascular protective properties, whereas high-density lipoprotein (HDL) is one of the most important. Beside cholesterol efflux, many pleiotropic cell-mediated functions of HDL are known so far. HDL is a spherical particle that contains different proteins and lipids. Especially sphingolipids, like sphingosine-1-phosphate (S1P), has gained great attention. The HDL associated S1P seems to be responsible for many of the pleiotropic effects of HDL by activating special S1P receptors...
High-Density Lipoprotein-Mediated Anti-Atherosclerotic and Endothelial-Protective Effects: A Potential Novel Therapeutic Target in Cardiovascular Disease.Authors: Besler C, Heinrich K, Riwanto M, Lüscher TF, Landmesser U
Reduced levels of high-density lipoprotein cholesterol (HDL) are associated with a substantially increased risk of coronary disease and cardiovascular events. Furthermore, numerous studies have suggested that HDL may exert several potentially important antiatherosclerotic and endothelial-protective effects. In particular, the promotion of reverse cholesterol transport, i.e. cholesterol efflux from lipid-loaded macrophages in atherosclerotic lesions and the subsequent cholesterol transport back to the liver, has been proposed as an anti-atherogenic effect of HDL that may promote regression of atherosclerotic lesions. Moreover, endothelial dysfunction is thought to play a critical role in development and progression ...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
HDL Quantity or Quality for Cardiovascular Prevention?Authors: Calabresi L, Gomaraschi M, Franceschini G
Plasma concentrations of HDL cholesterol (HDL-C) are strongly and inversely associated with cardiovascular risk, leading to the concept that therapies to enhance plasma HDL-C levels would be anti-atherogenic and protective against cardiovascular events. However, HDL are highly heterogeneous, with subclasses that can be separated and identified according to density, size, charge, and protein composition. There is evidence that these subclasses may differ in their functional anti-atherogenic properties. As a snapshot of the steady-state cholesterol carried by all HDL subclasses together, the individual HDL-C measurement is insufficient to capture the structural and functional variation in HDL particles. This review addresses the current ...
High-Density Lipoprotein at the Interface of Type 2 Diabetes Mellitus And Cardiovascular Disorders.Authors: Van Linthout S, Spillmann F, Schultheiss HP, Tschöpe C
Type 2 diabetes mellitus is associated with low high-density lipoprotein (HDL) cholesterol levels, which is an independent cardiovascular risk factor. Low HDL cholesterol concentrations reflect a dysregulation in HDL metabolism, which is determined by the concerted action of different proteins, including cholesterol ester transfer protein, lecithin: cholesterol acyltransferase, endothelial and lipoprotein lipase, phospholipid transfer protein, and hepatic lipase, as well as different receptors, including the scavenger receptor class B type I and ATP-binding cassette transporter A1 and G1. Type 2 diabetes mellitus is besides a dysregulation in HDL metabolism, also associated with dysfunctional HDL: HDL-mediated reverse...
High-Density Lipoprotein-Raising Strategies: Update 2010.Authors: Spillmann F, Schultheiss HP, Tschöpe C, Van Linthout S
Population studies have consistently shown that high-density lipoprotein (HDL) cholesterol levels are a strong, independent inverse predictor of cardiovascular disease. Every 1 mg/dl increase in HDL cholesterol is associated with a 2% to 3% decrease in coronary artery disease risk, independent of low-density lipoprotein (LDL) cholesterol and triglyceride levels. The primary mechanism for this protective effect is believed to be reverse cholesterol transport, but several other anti-inflammatory, anti-apoptotic, anti-oxidative functions for HDL have also been identified. Low HDL cholesterol is predictive of cardiovascular events in statin-treated patients with low LDL cholesterol, indicating that intensive lipid lowerin...
Gene Therapy to Improve High-Density Lipoprotein Metabolism and Function.Authors: Van Craeyveld E, Gordts S, Feng Y, Jacobs F, De Geest B
Plasma levels of high-density lipoprotein (HDL) cholesterol and its major apolipoprotein (apo), apo A-I, are inversely correlated with the incidence of ischemic cardiovascular diseases. Till now, evaluation of the hypothesis that elevation of HDL cholesterol reduces atherosclerotic burden and/or decreases ischemic cardiovascular events in humans has been hampered by the lack of drugs that selectively increase HDL cholesterol. In contrast to the lack of clinical data, evidence for a direct causal role of HDL in modulating atherogenesis in experimental models has been provided by investigations in human apo A-I transgenic mice and rabbits. The development of gene transfer technologies with a sufficiently high therapeutic in...
Support of drug therapy using functional foods and dietary supplements: focus on statin therapy.Authors: Eussen S, Klungel O, Garssen J, Verhagen H, van Kranen H, van Loveren H, Rompelberg C
Functional foods and dietary supplements might have a role in supporting drug therapy. These products may (1) have an additive effect to the effect that a drug has in reducing risk factors associated with certain conditions, (2) contribute to improve risk factors associated with the condition, other than the risk factor that the drug is dealing with, or (3) reduce drug-associated side effects, for example, by restoring depleted compounds or by reducing the necessary dose of the drug. Possible advantages compared with a multidrug therapy are lower drug costs, fewer side effects and increased adherence. In the present review we have focused on the support of statin therapy using functional food...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Effect of conjugated linoleic acid on body fat accretion in overweight or obese children.CONCLUSIONS: CLA supplementation for 7 +/- 0.5 mo decreased body fatness in 6-10-y-old children who were overweight or obese but did not improve plasma lipids or glucose and decreased HDL more than in the placebo group. Long-term investigation of the safety and efficacy of CLA supplementation in children is recommended.
PMID: 20200257 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
The glycosylphosphatidylinositol anchor is a major determinant of prion binding and replication.Authors: Bate C, Tayebi M, Williams A
The prion diseases occur following the conversion of the cellular prion protein (PrPC) into an alternatively folded, disease-related isoform (PrPSc). However, the spread of PrPSc from cell to cell is poorly understood. Here we report that soluble PrPSc bound to and replicated within both GT1 neuronal cells and primary cortical neurones. The capacity of PrPSc to bind and replicate within cells was significantly reduced by enzymatic modification of its glycosylphosphatidylinositol (GPI) anchor. Thus, PrPSc that had been digested with phosphatidylinositol-phospholipase C bound poorly to GT1 cells or cortical neurones and did not result in PrPSc formation in recipient cells. PrPSc that had been digested with phospholipase A2 (PrPSc-G-lyso-PI) bound rea...
Modulation of KvAP Unitary Conductance and Gating by 1-Alkanols and Other Surface Active Agents.Authors: Finol-Urdaneta RK, McArthur JR, Juranka PF, French RJ, Morris CE
The actions of alcohols and anesthetics on ion channels are poorly understood. Controversy continues about whether bilayer restructuring is relevant to the modulatory effects of these surface active agents (SAAs). Some voltage-gated K channels (Kv), but not KvAP, have putative low affinity alcohol-binding sites, and because KvAP structures have been determined in bilayers, KvAP could offer insights into the contribution of bilayer mechanics to SAA actions. We monitored KvAP unitary conductance and macroscopic activation and inactivation kinetics in PE:PG/decane bilayers with and without exposure to classic SAAs (short-chain 1-alkanols, cholesterol, and selected anesthetics: halothane, isoflurane, chloroform). At ...
HDL: Key Molecule in Cholesterol Efflux and the Prevention of Atherosclerosis.Authors: Meurs I, Van Eck M, Van Berkel TJ
Accumulation of cholesterol by macrophages, leading to their transformation into foam cells is a key event in the initiation of atherosclerosis. As maintenance of cholesterol homeostasis in macrophages is essential to prevent foam cell formation, mechanisms by which macrophages export cellular cholesterol have been intensively investigated in recent years. Several epidemiological studies have shown that plasma levels of high-density lipoprotein (HDL) cholesterol are inversely correlated with the risk of atherosclerosis. The protective effect of HDL against macrophage foam cell formation and atherosclerosis is primarily attributed to its role in reverse cholesterol transport (RCT), a process by which excess cholesterol in peripheral tissues is ...
Peroxisome Proliferator-Activated Receptor-{delta} Genotype Influences Metabolic Phenotype and May Influence Lipid Response to Statin Therapy in Humans: A Genetics of Diabetes Audit and Research Tayside Study.Conclusion: The current results suggest differential effects of PPARdelta in males and females.
PMID: 20200337 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Insulin Resistance Predicts Mortality in Non-Diabetic Persons in the United States.Conclusions: HOMA-IR is associated with all-cause mortality in the non-diabetic United States population but only among persons with normal BMI. HOMA-IR is a readily available measure that can be used in the future to predict mortality in clinical or epidemiological settings.
PMID: 20200308 [PubMed - as supplied by publisher] (Source: Diabetes Care)
Ogling Obama's lipidsAccording to almost every major American media outlet, Obama's total cholesterol levels have spiked from 173 in July 2008 to 209 in a recent checkup due to a rising LDL and a dipping HDL.
For complete story visit theheart.org. (Source: theHeart.org)
Statin primary prevention efficacy ‘equivalent in women and men’Statins are effective for the primary prevention of cardiovascular disease events in women, shows a gender-specific analysis of the JUPITER trial and an updated meta-analysis of relevant trials. (Source: MedWire News - Lipidology)
Health Buzz: The Best Way to De-Salt the American DietParents’ vaccine fears and kids’ health; taking an anticholesterol drug when cholesterol is normal. (Source: U.S. News - Health)
Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface [Chemistry]The recognition and binding of cholesterol is an important feature of many eukaryotic, viral, and prokaryotic proteins, but the molecular... (Source: Proceedings of the National Academy of Sciences)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Hypertension is a major risk factor for future atherosclerotic changes in the Japanese populationConclusion
The risk of future cardiovascular changes is significantly greater with higher SBP in the Japanese population. (Source: Annals of Clinical Biochemistry)
Investigation of the potential association of vitamin D binding protein with lipoproteinsConclusions
The lipid-bound DBP fraction may be of greater importance than initially thought. The present findings may have clinical consequences in view of the important physiological role of DBP. (Source: Annals of Clinical Biochemistry)
Automated assay for determining cellular cholesterol using a random access chemistry analyserConclusions
Using this technique, measurement of cellular cholesterol could be performed routinely without the requirement for special reagents and equipment. (Source: Annals of Clinical Biochemistry)
Middle-aged women's awareness of cholesterol as a risk factor: Results from a national survey of Korean Middle-aged Women's Health Awareness (KomWHA) studyConclusions: Given the low level of awareness and knowledge about cholesterol in these women, nurses need to increase their education about cholesterol and risk reduction behaviors of CVD for middle-aged Korean women, particularly those in rural area. To resolve identified disparities in women's risk reduction behaviors between the rural and urban area, a national-level health policy can result in a successful effort to promote women's awareness of cholesterol and risk reduction behaviors for the cardiovascular health of the public. (Source: International Journal of Nursing Studies)
Walking speed and subclinical atherosclerosis in healthy older adults: the Whitehall II studyConclusions
Short-distance walking speed is associated with metabolic risk and subclinical atherosclerosis in older adults without overt CVD. These data suggest that a non-aerobically challenging walking test reflects the presence of underlying vascular disease. (Source: Heart)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
New Report Warns: If You Take Simvastatin To Control Cholesterol, Watch Out For InfectionSimvastatin might help us control our cholesterol, but when it comes to infection, it's an entirely different story says a new research study published in the Journal of Leukocyte Biology (http://www.jleukbio.org). In the research report, scientists from Italy show that simvastatin delivers a one-two punch to the immune system. First it impairs the ability of specialized immune cells, called macrophages, to kill pathogens. Then, it enhances production of molecules, called cytokines, which trigger and sustain inflammation... (Source: Health News from Medical News Today)
New Report Warns: If You Take Simvastatin To Control Cholesterol, Watch Out For InfectionSimvastatin might help us control our cholesterol, but when it comes to infection, it's an entirely different story says a new research study published in the Journal of Leukocyte Biology (http://www.jleukbio.org). In the research report, scientists from Italy show that simvastatin delivers a one-two punch to the immune system... (Source: Cholesterol News From Medical News Today)
Pre- and post-treatment of streptozocin administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism.CONCLUSION: Melatonin pre-treatment prevents the injurious effects of streptozocin in rats. In streptozocin induced diabetic animals, post-treatment with this antioxidant normalizes both blood and liver constituents which were ameliorated by streptozocin.
PMID: 20187663 [PubMed - in process] (Source: Archives of Iranian Medicine)
Alteration of some natural anticoagulants in dogs with chronic renal failureThe objective of the study was to evaluate some parameters for assessing the prothrombotic
state in dogs with chronic renal failure (CRF). Some natural anticoagulants, protein C (PC), protein S (PS), and antithrombin
III (AT III), as well as fibrinogen concentration and clinical chemistries, were concentrated. The study groups consisted
of 42 dogs with CRF and 34 age- and sex-matched clinically healthy control dogs. The level of AT III in the CRF group was
significantly lower (P < 0.05), but the fibrinogen concentration was significantly higher (P < 0.05) than in the control group. Additionally, the cholesterol level in the CRF group was significantly higher than in the
control group (P < 0.05) and was positively correlated to creatinine (R = 0.5, P < 0...
Obama's other health downfall -- pieThe arugula-eating president's cholesterol count needs to come down, his doctor says. So besides quitting smoking, he'll have to start skipping dessert.
The famously self-disciplined president who seemingly can't miss a morning workout has a secret craving: pie. (Source: Los Angeles Times - Science)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Obama's other health downfall -- pieThe arugula-eating president's cholesterol count needs to come down, his doctor says. So besides quitting smoking, he'll have to start skipping dessert.
The famously self-disciplined president who seemingly can't miss a morning workout has a secret craving: pie. (Source: L.A. Times - Health)
Heart Warning Signs in Obese 3-Year-OldsTitle: Heart Warning Signs in Obese 3-Year-OldsCategory: Health NewsCreated: 3/2/2010 10:56:00 AMLast Editorial Review: 3/2/2010 10:56:13 AM (Source: MedicineNet Cholesterol General)
U.S. Has Racial Gap in Stroke RateTitle: U.S. Has Racial Gap in Stroke RateCategory: Health NewsCreated: 3/2/2010 10:19:00 AMLast Editorial Review: 3/2/2010 10:19:48 AM (Source: MedicineNet Cholesterol General)
Clot Buster More Critical for Female Stroke VictimsTitle: Clot Buster More Critical for Female Stroke VictimsCategory: Health NewsCreated: 3/1/2010 4:10:00 PMLast Editorial Review: 3/2/2010 (Source: MedicineNet Cholesterol General)
Popular Diet Plans Can Unclog ArteriesTitle: Popular Diet Plans Can Unclog ArteriesCategory: Health NewsCreated: 3/1/2010 4:10:00 PMLast Editorial Review: 3/2/2010 (Source: MedicineNet Cholesterol General)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Hormone Outperforms Insulin in Diabetic MiceTitle: Hormone Outperforms Insulin in Diabetic MiceCategory: Health NewsCreated: 3/1/2010 4:10:00 PMLast Editorial Review: 3/2/2010 (Source: MedicineNet Cholesterol General)
Cutting Salt Could Prevent Almost 500,000 Heart AttacksTitle: Cutting Salt Could Prevent Almost 500,000 Heart AttacksCategory: Health NewsCreated: 3/1/2010 6:10:00 PMLast Editorial Review: 3/2/2010 (Source: MedicineNet Cholesterol General)
Even the boss doesn't follow the doctor's orders(University of Michigan) Only 68 percent of corporate executives took their cholesterol lowering medication as prescribed by a doctor, a new study shows. (Source: EurekAlert! - Medicine and Health)
Even the boss doesn't follow the doctor's ordersOnly 68 percent of corporate executives took their cholesterol lowering medication as prescribed by a doctor, a new study shows. (Source: ScienceDaily Headlines)
Polymer Technology Systems, Inc. - PTS Panels Cholesterol test strips - Class 2 RecallPTS Panels Cholesterol test strips for self-testing or professional use with CardioChek analyzers, Manufactured by Polymer Technology Systems, Inc., Indianapolis, IN.Catalog # 1711. Intended to provide a quantitative measurement of total cholesterol in whole blood. (Source: Medical Device Recalls since July 07, 2006)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Single nucleotide polymorphisms in genes that are associated with a modified response to statin therapy: the Rotterdam StudyAuthors: C E de Keyser, M Eijgelsheim, A Hofman, E J G Sijbrands, A-H Maitland-van der Zee, C M van Duijn, A G Uitterlinden, J C M Witteman
& B H Ch Stricker (Source: The Pharmacogenomics Journal)
A comparison of the physico-chemical properties of low-cholesterol ghee with standard ghee from cow and buffalo creamsLow-cholesterol ghee with 90% less cholesterol was prepared using [beta]-cyclodextrin. The physico-chemical properties such as Reichert-Meissl (RM) value, Polenske value, Butyro-refractometer (BR) reading at 40°C, Iodine value and free fatty acids (FFA) as oleic acid in cow standard ghee and the corresponding low-cholesterol ghee remained almost unaltered. A similar trend was also observed in buffalo ghee. Fat soluble vitamins ([beta]-carotene, A and E) in both cow and buffalo low-cholesterol ghee were very similar to that of respective standard ghee samples. However, 65 to 70% loss of vitamin D was observed in low-cholesterol ghee. (Source: International Journal of Dairy Technology)
Resistance training in overweight women on a ketogenic diet conserved lean body mass while reducing body fatBackground:
The aim of the present study was to compare the effects of 10 weeks resistance training in combination with either a regular diet (Ex) or a low carbohydrate, ketogenic diet (Lc+Ex) in overweight women on body weight and body composition.
Methods:
18 untrained women between 20 and 40 years with BMI [greater than or equal to] 25 kg*m-2 were randomly assigned into the Ex or Lc+Ex group. Both groups performed 60-100 min of varied resistance exercise twice weekly. Dietary estimates were based on two 4-day weighed records. Body composition was estimated using Dual Energy X-ray Absorptiometry. Fasting blood samples were analyzed for total-, HDL- and LDL-cholesterol, triacylglycerols, and glucose.
Results:
16 subjects were included in the analyses. Percentage of energy (En%) from carbo...
Pulmonary embolism patients have low HDL cholesterolPatients with pulmonary embolism in the arterial trunk have significantly lower levels of high-density lipoprotein cholesterol than patients with pulmonary arterial non-trunk embolism, report researchers. (Source: MedWire News - Lipidology)
Oral Administration of the High-Chromium Yeast Improve Blood Plasma Variables and Pancreatic Islet Tissue in Diabetic Mice.Authors: Liu L, Jin W, Lv JP
The in vivo effects of oral administration of the high-chromium yeast to healthy and diabetic mice are described. Given that these complexes are proposed to function by potentiating the actions of insulin and activating the insulin receptor kinase, changes in lipid and carbohydrate metabolism would be expected. After 15 weeks administration (500 mug Cr/kg body mass) to healthy mice, abnormal metabolism and pathological change were not observed. After 15 weeks of treatment (0-1,000 mug Cr/kg body mass) of diabetic mice, the effect of high-chromium yeast on blood lipids and blood glycosylated hemoglobin (GHb) of diabetes are not consistent. High-chromium yeast results in a lowering (P < 0.05) of GHb and triglyceride, lowering (P < 0.01) of total cholest...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Dietary Intake and Serum and Hair Concentrations of Minerals and their Relationship with Serum Lipids and Glucose Levels in Hypertensive and Obese Patients with Insulin Resistance.Authors: Suliburska J, Bogdański P, Pupek-Musialik D, Krejpcio Z
Inadequate minerals intake, as well as disruption of some metabolic processes in which microelements are cofactors, are suggested to lead to the development of hypertension. The role of minerals in the pathogenesis of hypertension still remains to be explained. In the present study, we sought to determine associations between serum and hair mineral concentrations and serum lipids and glucose levels. Forty obese hypertensive subjects with insulin resistance and 40 healthy volunteers were recruited in the study. Blood pressure, BMI, and insulin resistance were recorded in all subjects. Levels of lipids, glucose, sodium and potassium, iron, copper, zinc, magnesium, and calcium were assessed in serum. Iron, copper, zinc...
Does the Long Plasma Half-Life of 4{beta}-Hydroxycholesterol Impact Its Utility as a Cytochrome P450 3A (CYP3A) Metric?Authors: Yang Z, Rodrigues AD
Plasma 4beta-hydroxycholesterol (4betaHC) has been proposed as an endogenous marker of cytochrome P450 3A (CYP3A). To assess its utility as a CYP3A metric, a pharmacokinetic model, assuming no alteration in cholesterol plasma concentrations, was developed to simulate the effect of CYP3A induction and inhibition on 4betaHC plasma levels under different treatment durations. By incorporating the long plasma half-life of 4betaHC (~17 days) into the model, the inductive effect of 2 known inducers (carbamazepine and rifampicin) reported in the literature was adequately described. Furthermore, the simulations showed that it was possible to resolve none, weak, moderate, and potent inducers within 2 weeks of dosing. On the other hand, simulations indicated that at ...
The metabolic syndrome: Prevalence, main characteristics and association with socio-economic status in adults living in Great Tunis.CONCLUSION: The prevalence of the MetS is markedly high within the population of Great Tunis and especially in women. As these findings predict future increases in cardiovascular disease in these populations, substantial efforts need to be made to fight against obesity and sedentary lifestyles to ameliorate the expected poor health outcomes.
PMID: 20202880 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
COX-2 Inhibitors Blunt "Preconditioning" Effect of StatinThe COX-2 inhibitor celecoxib completely abolished the beneficial preconditioning effect of rosuvastatin in a small mechanistic study in human volunteers. Heartwire (Source: Medscape Medical News Headlines)
COX-2 inhibitors blunt "preconditioning" effect of statinThe COX-2 inhibitor celecoxib completely abolished the beneficial preconditioning effect of rosuvastatin in a small mechanistic study in human volunteers.
For complete story visit theheart.org. (Source: theHeart.org)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Obama's cholesterol count blamed on dessertsPresident Barack Obama is trying to walk off a marginally high cholesterol count. (Source: CBC | Health)
Statins for Prevention? Taking a Cholesterol-Lowering Drug When Cholesterol Is NormalCrestor OK’d for broader use; FDA says those with normal cholesterol but high inflammation now qualify. (Source: U.S. News - Health)
Obama trying to walk off marginally high cholesterolPoll results, congressional head counts and U.S. government federal are not the only numbers President Barack Obama has to worry about. Now, he is trying to walk off a marginally high cholesterol count. (Source: CTV Health)
MicroRNAs in atherosclerosis and lipoprotein metabolismPurpose of review: MicroRNAs (miRNA) are mediators of post-transcriptional gene expression that likely regulate most biological pathways and networks. The study of miRNAs is a rapidly emerging field; recent findings have revealed a significant role for miRNAs in atherosclerosis and lipoprotein metabolism, which will be described in this review.
Recent findings: The discovery of miRNA gene regulatory mechanisms contributing to endothelial integrity, macrophage inflammatory response to atherogenic lipids, vascular smooth muscle-cell proliferation, and cholesterol synthesis are described. Furthermore, recent evidence suggests that miRNAs may play a role in mediating the beneficial pleiotropic effects observed with statin-based lipid-lowering therapies. New modifications to miRNA mimetics and...
The promise of apolipoprotein A-I mimeticsPurpose of review: Synthetic high-density lipoprotein (HDL) and apolipoprotein (apo) A-I mimetic peptides emulate many of the atheroprotective biological functions attributed to HDL and can modify atherosclerotic disease processes. Administration of these agents as HDL replacement or modifying therapy has tremendous potential of providing new treatments for cardiovascular disease. Progress in the understanding of these agents is discussed in this review.
Recent findings: Prospective, observational, and interventional studies have convincingly demonstrated that elevated serum levels of high-density lipoprotein-cholesterol (HDL-C) are associated with reduced risk for coronary heart disease (CHD). Although traditional pharmacological agents have shown modest utility in raising HDL levels and...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Obama's Physical Shows He Still SmokesPresident Barack Obama hasn't kicked the smoking habit, takes anti-inflammatory medication to relieve chronic tendinitis in his left knee and should eat better to lower his cholesterol, his team of doctors concluded Sunday. (Source: WDSU.com - Health)
Low vitamin D levels in children associated with higher plasma glucose and lower HDLA retrospective record review of pediatric outpatients (age, 2-18 years) included simultaneous measurement of 25-hydroxyvitamin D (25[OH] D) and fasting plasma glucose or 25(OH) D and a lipid panel.25(OH) D levels were inversely correlated with fasting plasma glucose levels. Lower 25(OH) D levels were also associated with lower serum high-density lipoprotein cholesterol (HDL) concentrations. Children who were vitamin D insufficient (25[OH] D ≤30 ng/mL) had higher fasting plasma glucose and lower HDL levels than children who were vitamin D sufficient (25[OH] D >30 ng/mL). References:http://www.jpeds.com/article/PIIS0022347609009858/abstractImage sources: Wikipedia, public domain.
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Doc Declares Obama in "Excellent Health"President Advised to Step-Up "Smoking Cessation Efforts," Lower Cholesterol in 1st White House Checkup (Source: Health News: CBSNews.com)
Doc Declares Obama in "Excellent Health"President Advised to Step-Up "Smoking Cessation Efforts," Lower Cholesterol in 1st White House Checkup (Source: Health News: CBSNews.com)
Controlling cholesterol in childrenSome new drugs may have risks, but the risks may be worth taking. For other kids, diet and exercise are the better treatment.
Doctors may not agree on the need to screen children for high cholesterol, but those who do will likely want to treat kids with abnormal results. (Source: L.A. Times - Health)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Obama in excellent health, doctor says, but he should quit smokingThe president undergoes his first physical exam since entering office. He's declared 'fit for duty,' but there is some concern about his elevated cholesterol levels.
President Obama is fit as a fiddle, but he should lower his cholesterol and kick his smoking habit. (Source: Los Angeles Times - Science)
Obama in excellent health, doctor says, but he should quit smokingThe president undergoes his first physical exam since entering office. He's declared 'fit for duty,' but there is some concern about his elevated cholesterol levels.
President Obama is fit as a fiddle, but he should lower his cholesterol and kick his smoking habit. (Source: L.A. Times - Health)
Why pharmaceuticals might be called Weapons of Mass Prescription(NaturalNews) Most people are familiar with traditional weapons of mass destruction such biological weapons, nuclear weapons and chemical weapons. The point of all such weapons of mass destruction is to inflict a large number of casualties on civilian populations as a way to cripple a nation into political or military submission.When it comes to actually deploying weapons of mass destruction (WMDs) against civilian populations, no country has murdered more innocent civilians than the United States of America through its bombing of two Japanese cities during World War II. (This isn't rhetoric, it's an historical fact.)Atomic bombs were very visible WMDs deployed in World War II as a way to force the empire of Japan to surrender to western forces. Since that time, full-scale nuclear weapons ...
Pharmaceuticals are Weapons of Mass Prescription (comic)(NaturalNews) Most people are familiar with traditional weapons of mass destruction such biological weapons, nuclear weapons and chemical weapons. The point of all such weapons of mass destruction is to inflict a large number of casualties on civilian populations as a way to cripple a nation into political or military submission.When it comes to actually deploying weapons of mass destruction (WMDs) against civilian populations, no country has murdered more innocent civilians than the United States of America through its bombing of two Japanese cities during World War II. (This isn't rhetoric, it's an historical fact.)Atomic bombs were very visible WMDs deployed in World War II as a way to force the empire of Japan to surrender to western forces. Since that time, full-scale nuclear weapons ...
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