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Arimidex and weight gain:
(sometimes called an AI). It is usually provided in 1MG tabs or in liquid form. The drug works in a non-steroid form by inhibiting the aromatase enzyme which convertstestosterone and other androgens into estrogen. This means that there is less estrogen tocause female pattern fat deposits, gyno, and water retention. In medicine, Arimidex isutilized to treat prostate cancer. In sports chemistry, the drug has been employed as ameans of preventing excessive estrogenic side effects during AAS use and to aid increating a harder appearing musculature for competitive bodybuilders. Unlike Nolvadex,which simply block estrogen receptor-sites, this drug prevents or reduces estrogenproduction. Though some estrogen presence is noted as necessary for AAS to reach fulleffectiveness, too much can cause a layer of fat, water retention, and breast tissue growthpotentially with tumors called gynecomastia or bitch tits. Arimidex has a 75-85%aromatization inhibition rate. Males who experienced excessive aromatization of AAS or who were extremelyestrogen sensitive usually utilized a dosage of 0.5-3.0 mg daily. In fact, most realizedexcellent estrogen control with only 0.5mg/d (mg daily). Women usually showedexcellent lean appearances (even in their legs) with 0.5-1.0 mg daily. Arimidex has a veryshort active-life so 0.5 mg dosages were often taken 2-6 times daily at equal intervals.Stacking 10-30 mg of Nolvadex with 1.0 mg of Arimidex has resulted in a near "0"estrogen activity situation regardless of the AAS protocol utilized. Directly following anAAS cycle, estrogen control has also become a problem (during periods intended for reestablishingHPTA function). In this case, the dosage was reduced from a higher startingdosage to a low dosage that was continued for 7-14 days after AAS discontinuance. Thisprotocol was considered necessary to assure clearing of AAS induced estrogen build-up.
Reported Characteristics
Active-Life: 4-6 hours Drug Class: Aromatase inhibitor (Oral) Average Reported Dosage: 0.5-3.0 mg daily Acne: No Water Retention: None Liver Toxic: Yes dosage dependent Decreases HPTA function: Increases it.
TRADE NAMES:
ARIMIDEX .25 MG TABS (International Pharmaceuticals) ARIMIDEX 1mg TABS (British Dragon)
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| Ruptured intracranial dermoid cyst presenting with neuropsychiatric symptoms: a case report.The diagnosis of a ruptured dermoid cyst in a 58-year-old man with chronic psychiatric problems is described. The auditory and visual neuropsychiatric problems resulted from irritation of brain structures by cholesterol particles from the ruptured dermoid cyst. Extirpation of the cyst and it ruptured contents reversed two of the three chronic symptoms and both of the acute symptoms.Page: 98DOI: 10.1097/SMJ.0b013e318188b290Authors: Detweiler, Mark B. MD, MS; David, Efraim MD; Arif, Saira MD (Source: Southern Medical Journal) MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.
Studies of raising hdl cholesterol: updates at esc 2008ESC08: In addition to data-mining the famous 4S results, new results with pravastatin, ApoA-1 Milano, niacin, and fibrates support the next big step: raising HDL-C levels.
Medscape Cardiology (Source: Medscape Cardiology Headlines)
Further doubts over ezetimibeMore uncertainty has been cast on the use of the cholesterol-lowering drug ezetimibe, after a trial showed adding the drug to statin treatment made little difference to outcomes. (Source: Pulse Today Clinical Updates)
New york times examines how ehrs could improve evidence-based medicineThe New York Times last week examined how "widespread adoption of electronic health records might ... greatly increase evidence-based medicine," among other benefits. The article is part of an occasional Times series called "The Evidence Gap." According to the Times, "Each patient's records adds to a real-time, ever-growing database of evidence showing what works and what does not" that could allow physicians to "harness health information from individuals and populations, share it across networks, sift it and analyze it to make the practice of medicine more of a science and less an art."The Times profiles the Marshfield Clinic in Wisconsin, which uses a number of health information technology tools to improve health care quality and efficiency. The Times reports that the Marshfield experi...
Leptin and coronary heart disease: prospective study and systematic reviewConclusions
Previous studies appear to have overestimated associations of leptin and CHD risk. Our results suggest a moderate association that is largely dependent on BMI. (Source: Journal of the American College of Cardiology)
Design of fitfor2 study: the effects of an exercise program on insulin sensitivity and plasma glucose levels in pregnant women at high risk for gestational diabetes.DiscussionIf the FitFor2 intervention program proves to be effective, obstetricians and midwives should refer women at risk for GDM to a special exercise program. Exercise programs for pregnant women under supervision of an experienced trainer are already available in the Netherlands, and these programs could be adjusted easily for this target group. Furthermore, the costs of these programs should be refunded by including them in the basic health care cost reimbursement schemes.
Trial registration: NTR1139 (Source: BioMed Central) MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.
Young age and exercise protect against ldl-cholesterol-related cvd riskYounger age and regular exercise seem to protect against the adverse effects of moderately high low-density lipoprotein cholesterol on endothelium-dependent dilation in men, report scientists in the American Journal of Hypertension. (Source: MedWire News - Lipidology)
The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat modelConclusion. Together, these results indicated that high-fat diet combined with multiple low doses of STZ (30 mg/kg at weekly intervals for 2 weeks) proved to be a better way for developing a stable animal model of type 2 diabetes, and this new model may be suitable for pharmaceutical screening. (Source: Experimental Diabetes Research)
Health fears grow as fake drugs flood into britainThey were made in China, labelled in French and then shipped to Singapore. They ended up in Liverpool and from there were sold straight into the heart of the NHS. As the criminal investigation continues into how a fake consignment of Zyprexa, an anti-psychotic treatment prescribed for schizophrenia, infiltrated Britain's healthcare system last year, evidence is mounting that sophisticated counterfeiting syndicates are increasingly targeting Britain's network of high-street chemists, hospitals and GP surgeries.Figures collated for the first time reveal that British border officials seized more than half a million counterfeit pills destined for the NHS and high-street chemists last year, an amount equal to the quantity of counterfeit drugs found in the whole of Europe in 2005. So vast is the...
Statin therapy lowers cv events but not blood pressure in cafe-lla studyResults from the CAFE-LLA study show that although statin therapy reduces cardiovascular events in hypertensive patients, it does not appear to influence aortic blood pressure or hemodynamics. (Source: MedWire News - Hypertension)
Hepatic sirna delivery using recombinant human apolipoprotein a-i in mice.In this study, we expressed and purified recombinant human apo A-I (rhapo A-I), low endotoxin grade, from an Escherichia coli expression system. The liver-targeting property of rhapo A-I was compared to that of plasma-derived apo A-I. Using a hepatitis C virus mouse model, intravenous administration of virus-specific siRNA with liposome and rhapo A-I significantly inhibited viral protein expression, demonstrating great promise for its use in clinical applications.
PMID: 19017527 [PubMed - indexed for MEDLINE] (Source: Biochemical and Biophysical Research communications) MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.
Glycosphingolipid deficiency increases the sterol regulatory element-mediated gene transcription.In this study, we examined the effects of GSL depletion on SRE-mediated gene transcription using GSL-defective cells. We found that the content of mature SREBP, the transcriptional active form, is increased in the GSL-defective cells. Transcription of SREBP target genes and cholesterol synthesis are also induced in the GSL-defective cells. These results indicate that GSL deficiency up-regulates the SREBP pathway, pointing out the regulatory role of GSL in cholesterol homeostasis.
PMID: 19017528 [PubMed - indexed for MEDLINE] (Source: Biochemical and Biophysical Research communications)
Abcg2 is expressed in late spermatogenesis and is associated with the acrosome.ABCG2 is expressed in late spermatogenesis and is associated with the acrosome.
Biochem Biophys Res Commun. 2009 Jan 9;378(2):302-7
Authors: Scharenberg C, Mannowetz N, Robey RW, Brendel C, Repges P, Sahrhage T, Jähn T, Wennemuth G
An increasingly exploited strategy for the isolation of stem cells is based on the increased efflux of Hoechst 33342 lipophilic dye mediated by ABCG2, an ATP-binding cassette transporter which is highly expressed in various stem cells. We found ABCG2 expression to be present at later stages of spermatogenesis. Western blot analysis using an anti-ABCG2 antibody revealed expression of a 72kDa band in mature sperm obtained from mice, rats, bulls or humans. Immunocytochemistry studies revealed acrosomal staining pattern of ABCG2 in spermatozoa. Expe...
Single letter in human genome points to risk for high cholesterolWrite out every letter in the human genome, one A, C, T or G per millimeter, and the text would be 1,800 miles long, roughly the distance from New York to Colorado. Now, in the search for genes that affect how humans synthesize, process and break down cholesterol, scientists have found a single letter among this expanse of code that is associated with elevated LDL cholesterol levels, one of the leading health concerns that has come to dominate the 21st century. (Source: ScienceDaily Headlines)
Cafe-lla: statin therapy does not influence central aortic pressure or hemodynamicsStatins are beneficial in patients with hypertension but have no effect on central aortic pressures, pulse-wave augmentation, or any other central hemodynamic parameter. Medscape Medical News (Source: Medscape Medical News Headlines)
Health highlights: jan. 1, 2009Title: Health Highlights: Jan. 1, 2009Category: Health NewsCreated: 1/2/2009 2:00:00 AMLast Editorial Review: 1/2/2009 (Source: MedicineNet Cholesterol General) MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.
Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neuronsIn conclusion, RST preconditions cultured neurons against OGD via depletion of GGPP, leading to decreased geranylgeranylation of proteins that are probably not isoprenylated by GGT 1. Reduced neuronal ATP levels and ROS production after OGD may be directly involved in the mechanism of neuroprotection. (Source: AJP: Cell Physiology)
Surprises and reaffirmations in 2008 clinical trialsClinical trials in 2008 showed us that too much glucose is bad, but trying too hard to lower it may be worse. Low-density lipoprotein cholesterol promotes cardiovascular morbidity, and starts to do so even when the person is apparently healthy. (Source: Cleveland Clinic Journal of Medicine)
Jupiter to earth: a statin helps people with normal ldl-c and high hs-crp, but what does it mean?How low should we go with low-density lipoprotein cholesterol, and at what cost? What is the role of screening C-reactive protein? The JUPITER study partially answered these questions. (Source: Cleveland Clinic Journal of Medicine)
Free cholesterol accumulation in macrophage membranes activates toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin k.Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K.
Circ Res. 2009 Jan 2;
Authors: Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR
The molecular events linking lipid accumulation in atherosclerotic plaques to complications such as aneurysm formation and plaque disruption are poorly understood. BALB/c-Apoe(-/-) mice bearing a null mutation in the Npc1 gene display prominent medial erosion and atherothrombosis, whereas their macrophages accumulate free cholesterol in late endosomes and show increased cathepsin K (Ctsk) expression. We now show increased cathe...
The antiangiogenic activity of rpai-123 inhibits vasa vasorum and growth of atherosclerotic plaque.In conclusion, rPAI-123 inhibits growth of vasa vasorum, as well as vessels within the adjacent plaque and vessel wall, through inhibition of fibroblast growth factor-2, leading to reduced plaque growth in atherogenic female LDLR(-/-)ApoB-48-deficient mice.
PMID: 19122176 [PubMed - as supplied by publisher] (Source: Circulation Research) MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.
Relationship of ethnic origin, gender, and age to blood creatine kinase levels.CONCLUSION: Physicians should use caution when interpreting creatine kinase levels that seem elevated, particularly when treating African American patients and younger men.
PMID: 19114174 [PubMed - in process] (Source: The American Journal of Medicine)
Long-term c-reactive protein variability and prediction of metabolic risk.CONCLUSION: The results of this longitudinal analysis suggest the intraindividual, long-term variability of CRP concentrations is relatively small and predictive of new diabetes over an intermediate-term of 4 years.
PMID: 19114172 [PubMed - in process] (Source: The American Journal of Medicine)
Statin-induced myopathy: hypothesis about randomized evidence and clinical impressions.Authors: Hennekens CH
PMID: 19114161 [PubMed - in process] (Source: The American Journal of Medicine)
Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? a randomized, controlled study.CONCLUSIONS: Even if total cholesterol and HDL-C were significantly reduced, the clinical magnitude of this remains obscure. More and larger studies are needed to establish effects and safety of guggul-based formulations in the treatment for hypercholesterolemia.
PMID: 19114224 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Increased acylation-stimulating protein, c-reactive protein, and lipid levels in young women with polycystic ovary syndromeConclusion(s): Levels of ASP, CRP, and lipids are increased in subjects with PCOS, regardless of the level of BMI. The increased ASP level in both PCOS groups suggests that the ASP metabolism may be altered. (Source: Fertility and Sterility) MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.
Mechanisms mediating androgen receptor reactivation after castration.Authors: Yuan X, Balk SP
Androgen deprivation is still the standard systemic therapy for metastatic prostate cancer (PCa), but patients invariably relapse with a more aggressive form of PCa termed hormone refractory, androgen independent, or castration resistant PCa (CRPC). Significantly, the androgen receptor (AR) is expressed at high levels in most cases of CRPC, and these tumors resume their expression of multiple AR-regulated genes, indicating that AR transcriptional activity becomes reactivated at this stage of the disease. The molecular basis for this AR reactivation remains unclear, but possible mechanisms include increased AR expression, AR mutations that enhance activation by weak androgens and AR antagonists, increased expression of transcriptional coactivator proteins, and a...
Microvascular and macrovascular complications in diabetic nephropathy patients referred to nephrology clinic.Authors: Al-Wakeel JS, Hammad D, Al Suwaida A, Mitwalli AH, Memon NA, Sulimani F
To evaluate the diabetic complications and fate of diabetic nephropathy in Saudi population, we studied 184 diabetic nephropathy (DN) patients who were referred to nephrology clinic of King Khalid University Hospital, Riyadh, Saudi Arabia from January 2003-June 2006. The patients had mean age of 61.9 +/- 13.1 years, included 128 (69.6%) males, and were followed up for a mean period of 10.2 +/- 1.5 years. The mean duration of diabetes mellitus (DM) was 19.5 +/- 5.8 years, and duration of nephropathy was 7.7 +/- 3.3 years. Family history of DN was documented in 52 (28.2%) patients. At initial visit, the mean systolic blood pressure was 164 +/- 14.5 mmHg, the mean diastolic blood pressure was 97.9 +/- 10.4 mm...
Prevalence and control of diabetes and impaired fasting glucose in new york city.CONCLUSIONS: In New York City, diabetes and IFG are widespread. Policies and structural interventions to promote physical activity and healthy eating should be prioritized. Improved disease management systems are needed for people with diabetes.
PMID: 19114627 [PubMed - in process] (Source: Diabetes Care)
Alteration of 11beta-hydroxysteroid dehydrogenase type 1 in skeletal muscle in a rat model of type 2 diabetes.Authors: Zhang M, Lv XY, Li J, Xu ZG, Chen L
Recent investigations have demonstrated that activation of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in liver and adipose tissue is closely related to the pathogenesis of obesity and diabetes. However, the relationship between alteration of 11beta-HSD1 and the pathogenesis of type 2 diabetes in skeletal muscle is still unclear. A rat model of Type 2 diabetes was developed by high fat diet feeding combined with multiple low dose streptozotocin injection (30 mg/kg, i.p. twice). Intraperitoneal glucose tolerance test, insulin tolerance test were performed. Fasting blood glucose, fasting insulin, total cholesterol, triglyceride were measured. The protein and mRNA level of 11beta-HSD1 and glucocorticoid receptor in gastrocnemius mu...
Cafe-lla: statin therapy does not influence central aortic pressure or hemodynamicsAlthough statins have been shown to have beneficial clinical effects in hypertensive patients, researchers state the "favorable effects are via mechanisms that are independent of important effects on large-artery function and central pressure." Heartwire (Source: Medscape Medical News Headlines) MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.
Optimal warfarin dosing improves anticoagulation controlTitle: Optimal Warfarin Dosing Improves Anticoagulation ControlCategory: Health NewsCreated: 12/31/2008 2:00:00 AMLast Editorial Review: 12/31/2008 (Source: MedicineNet Cholesterol General)
America losing the fight with type 2 diabetesTitle: America Losing the Fight With Type 2 DiabetesCategory: Health NewsCreated: 12/31/2008 2:00:00 AMLast Editorial Review: 12/31/2008 (Source: MedicineNet Cholesterol General)
Experimental evidence suggestive of early intervention in mucoid otitis media.Conclusions. Mucoid effusion can undergo a process of organization related to the inflammatory process and hypoventilation; organized effusion in the presence of epithelial breaks is a potential source for formation of granulation tissue and cholesterol granuloma within 3 months of evolution. Objectives. The aim of this study was to investigate the evolution of mucoid otitis media and its relationship with the organized effusion within a time-span of 3 months. Materials and methods. Two groups of animals were selected. In group I, 15 chinchillas had a chemically modified bovine collagen type 2 gelatin membrane placed through a mechanically induced tympanic membrane perforation, bridging the external auditory canal and the promontory. In group II, 75 cats underwent eustachian tube obstructi...
Inhibition of hmgcoa reductase reveals an unexpected role for cholesterol during pgc migration in the mouseConclusions:
In the mouse, cholesterol is required for PGC survival and motility. It may act cell-autonomously by regulating clustering of growth factor receptors within PGCs or non cell-autonomously by controlling release of growth factors required for PGC guidance and survival. (Source: BMC Developmental Biology - Latest articles)
Detergent resistant membrane-associated ide in cultured cells and brain tissue: relevance to abeta and insulin degradationConclusions:
Our results support the notion that optimal substrate degradation by IDE may require its association with organized-DRMs. Alternatively, DRMs but not other plasma membrane regions, may act as platforms where Abeta accumulates, due to its hydrophobic properties, reaching local concentration close to its Km for IDE facilitating its clearance. Structural integrity of DRMs may also be required to tightly retain insulin receptor and IDE for insulin proteolysis. The concept that mis-location of Abeta degrading proteases away from DRMs may impair the physiological turn-over of Abeta in vivo deserves further investigation in light of therapeutic strategies based on enhancing Abeta proteolysis in which DRM protease-targeting may need to be taken into account. (Source: Molecular Neurode... MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.
Mechanisms of aortic and cardiac dysfunction in uremic mice with aortic calcification.Conclusions-In a mouse model of CRF, left ventricular hypertrophy, cardiac diastolic dysfunction, and increased aortic stiffness were not related to structural changes in the aorta (including aortic calcification) or high serum cholesterol levels. However, cardiac and aortic abnormalities were associated with the extent of subendothelial dysfunction and the severity of CRF.
PMID: 19118252 [PubMed - as supplied by publisher] (Source: Circulation)
Co-solvent evaporation method for enhancement of solubility and dissolution rate of poorly aqueous soluble drug simvastatin: in vitro-in vivo evaluation.Co-solvent Evaporation Method for Enhancement of Solubility and Dissolution Rate of Poorly Aqueous Soluble Drug Simvastatin: In vitro-In vivo Evaluation.
AAPS PharmSciTech. 2008 Dec 31;
Authors: Pandya P, Gattani S, Jain P, Khirwal L, Surana S
A number of synthesized chemical molecules suffer from low aqueous solubility problems. Enhancement of aqueous solubility, dissolution rate, and bioavailability of drug is a very challenging task in drug development. In the present study, solubility and dissolution of poorly aqueous soluble drug simvastatin (SIM) was enhanced using hydrophilic, low viscosity grade polymer hydroxypropyl methylcellulose (HPMC K(3)LV). The co-solvent evaporation method was developed for efficient encapsulation of hydrophobic drug in polymer micelles of HPMC ...
Why lipids are important for alzheimer disease?Why lipids are important for Alzheimer disease?
Mol Cell Biochem. 2008 Dec 31;
Authors: Hirsch-Reinshagen V, Burgess BL, Wellington CL
Several lines of evidence suggest that dysregulated lipid metabolism may participate in the pathogenesis of Alzheimer's disease (AD). Epidemiologic studies suggest that elevated mid-life plasma cholesterol levels may be associated with an increased risk of AD and that statin use may reduce the prevalence of AD. Cellular studies have shown that the levels and distribution of intracellular cholesterol markedly affect the processing of amyloid precursor protein into Abeta peptides, which are the toxic species that accumulate as amyloid plaques in the AD brain. Most importantly, genetic evidence identifies apolipoprotein E, the major cholesterol car...
Diet-induced alterations in intestinal and extrahepatic lipid metabolism in liver fatty acid binding protein knockout mice.Authors: Newberry EP, Kennedy SM, Xie Y, Luo J, Davidson NO
Liver fatty acid binding protein (L-FABP) is highly expressed in both enterocytes and hepatocytes and binds multiple ligands, including saturated (SFA), unsaturated fatty acids (PUFA), and cholesterol. L-fabp (-/-) mice were protected against obesity and hepatic steatosis on a high saturated fat (SF), high cholesterol "Western" diet and manifested a similar phenotype when fed with a high SF, low cholesterol diet. There were no significant differences in fecal fat content or food consumption between the genotypes, and fatty acid (FA) oxidation was reduced, rather than increased, in SF-fed L-fabp (-/-) mice as evidenced by decreased heat production and serum ketones. In contrast to mice fed with a SF diet, L-fabp (-/-) mice fed ...
The role of alpha-synuclein in brain lipid metabolism: a downstream impact on brain inflammatory response.Authors: Golovko MY, Barceló-Coblijn G, Castagnet PI, Austin S, Combs CK, Murphy EJ
alpha-Synuclein (Snca) is an abundant small cytosolic protein (140 amino acids) that is expressed in the brain, although its physiological role is poorly defined. Consistent with its ubiquitous distribution in the brain, we and others have established a role for Snca in brain lipid metabolism and downstream events such as neuroinflammation. In astrocytes, Snca is important for fatty acid uptake and trafficking, where its deletion decreases 16:0 and 20:4n-6 uptake and alters targeting to specific lipid pools. Although Snca has no impact on 22:6n-3 uptake into astrocytes, it is important for its targeting to lipid pools. Similar results for fatty acid uptake from the plasma are seen in studies using ... MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.
Apolipoprotein(a): a natural regulator of inflammationIn a study to be published in the January 09 issue of Experimental Biology and Medicine, Hoover-Plow and co-workers in seeking to define a role of apo(a) in leukocyte recruitment have identified a novel activity of apo(a) apolipoprotein that may function as a natural and cell specific suppressor of the inflammatory response in vivo. In addition, a mechanism for this novel function of apo(a) was also identified: its selective regulation of cytokine production. (Source: Cholesterol News From Medical News Today)
Gene linked to high blood pressure discoveredTitle: Gene Linked to High Blood Pressure DiscoveredCategory: Health NewsCreated: 12/30/2008 2:00:00 AMLast Editorial Review: 12/30/2008 (Source: MedicineNet Cholesterol General)
Surgery reverses type 2 diabetes in teensTitle: Surgery Reverses Type 2 Diabetes in TeensCategory: Health NewsCreated: 12/30/2008Last Editorial Review: 12/30/2008 (Source: MedicineNet Cholesterol General)
High blood sugar linked to memory lossTitle: High Blood Sugar Linked to Memory LossCategory: Health NewsCreated: 12/30/2008Last Editorial Review: 12/30/2008 (Source: MedicineNet Cholesterol General)
Researchers at columbia university medical center link blood sugar to normal cognitive agingDecember 30, 2008 (EurekAlert) – Maintaining blood sugar levels, even in the absence of disease, may be an important strategy for preserving cognitive health, suggests a study published by researchers at Columbia University Medical Center (CUMC). The study appeared in the December issue of Annals of Neurology.
Senior moments, also dubbed by New York Times Op-Ed columnist David Brooks as being "hippocampically challenged," are a normal part of aging. Such lapses in memory, according to this new research, could be blamed, at least in part, on rising blood glucose levels as we age. The findings suggest that exercising to improve blood sugar levels could be a way for some people to stave off the normal cognitive decline that comes with age.
"This is news even for people without diabetes... MedWorm Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.
Application of maldi-tof mass spectrometry in lipidomicsLipids are of high interest on different levels. First, lipids as triacylglycerols (TAG) (particularly different vegetable oils) are of immense commercial interest. Second, lipids are of high relevance for different in vivo processes. For instance, the diagnostics of changes of the lipoproteins of human blood is very important in vascular diseases, whereas phospholipids (PL) are crucial for the properties of the cellular membrane and some selected PL were also recognized to represent important second messengers. Although there are many different methods (including different chromatographic and spectroscopic approaches) available, mass spectrometry (MS) is the most versatile tool of lipid analysis, with or without prior separation steps. Although several different ionization techniques are ...
A case report of an adult with severe hyperlipidemia during acute lymphocytic leukemia induction therapy successfully treated with plasmapheresisWe report here on a case showing severe hypertriglyceridemia during asparaginase (Asp) treatment for acute lymphocytic leukemia (ALL), and give an overview of a lipid-lowering apheresis therapy. To prevent the complication of pancreatitis due to hypertriglyceridemia, we performed plasma exchange (PE) three times using fresh frozen plasma. PE remarkably reduced both serum triglyceride and total cholesterol levels from 5430 mg/dL to 403 mg/dL and from 623 mg/dL to 204 mg/dL, respectively. The causes of severe hyperlipidemia in this patient were considered to include: the Asp treatment for ALL, and a genetic background with a heterozygote of familial lipoprotein lipase (LPL) defect syndrome, because the patient's plasma LPL level after intravenous heparin injection was low at 137 ng/mL. Hence...
Researchers at columbia university medical center link blood sugar to normal cognitive agingDecember 30, 2008 (EurekAlert) ??? Maintaining blood sugar levels, even in the absence of disease, may be an important strategy for preserving cognitive health, suggests a study published by researchers at Columbia University Medical Center (CUMC). The study appeared in the December issue of Annals of Neurology.
Senior moments, also dubbed by New York Times Op-Ed columnist David Brooks as being "hippocampically challenged," are a normal part of aging. Such lapses in memory, according to this new research, could be blamed, at least in part, on rising blood glucose levels as we age. The findings suggest that exercising to improve blood sugar levels could be a way for some people to stave off the normal cognitive decline that comes with age.
"This is news even for people without diabetes...
Expression of sterol regulatory element binding transcription factor (srebf) 2 and srebf cleavage-activating protein (scap) in human atheroma and the association of their allelic variants with sudden cardiac deathConclusions:
The results suggest that the allelic variants (SREBF-2 1784G>C and SCAP 2386A>G) in the cholesterol homeostasis regulating SREBF-SCAP pathway may contribute to SCD in early middle-aged men. (Source: Thrombosis Journal)
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